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We design the most sophisticated optics, mechanics, and software to create one microscope built for the sole purpose of in vivo brain imaging with unrivaled signal detection.

Importantly, we also run our own laboratories. We know that all of this technology isn't worth much if students and postdocs cannot use it. That's why we make everything user friendly and we provide a host of powerful analytical tools and live consultation to get even first year students up and running fast.

Our system is designed from the ground up, completely optimized for the latest generation of in vivo calcium imaging neuroscience experiments. Without starting from an existing microscope body, the system implements a translating microscope, designed with large clearance for behavior.

From laser optics to signal detection to digitization, it is end-to-end optimized to maximize signal-to-noise ratio and enable precise and crisp imaging.

Optimized Path

Modeled and optimized scan and detection paths. Back-aperture conjugated detection for maximum scattered light detection for 10X-40X objectives. Standard systems ship with two detection channels, and a computer controlled path switch for an included camera and optional epifluorescence path. Light-sealed for visual stimulus and behavior.

Motion

Adjust height manually without adjusting alignment along a high-carbon steel rail. Motorized XYZ-theta translation is controlled via a rotary interface, with an envelope of 100mm in all directions and +/- 60 degree angle

2P Optogenetics

Designed for all-optical interrogation of neural circuits. Optogenetically drive membrane currents with exquisite control.